Polymer Solubility in Solvents

Table: Solubility of carbohydrate polymers in different solvents. Each entry gives the polymer, solvent, concentration (mg/mL), the solubility class (soluble: transmission > 85 %; partially soluble: 10-85 %; insoluble: < 10 %), the percent transmission at 10, 25 and 60 °C on the cooling ramp, and the approximate cloud point (°C). Classes describe nonequilibrium behaviour at a 0.5 °C/min ramp, not thermodynamic solubility. Click any column header to sort.

#	Polymer	Solvent	Conc. (mg/mL)	Mn (g/mol)	Solubility class	T% at 10 °C	T% at 25 °C	T% at 60 °C	Cloud point (°C)	Method	Conditions	Ref (DOI)	Comments
1	Cellulose acetate	1,4-dioxane	15.01	50000	Partially soluble	56	100	100	16	Experiment	15.01 mg/mL, 10-60 °C, 0.5 °C/min Crystal16 turbidity (645 nm), cooling ramp 60 to 10 °C at 0.5 °C/min after two heat/cool cycles; holds 120 min at 10 °C and 60 min at 60 and 25 °C; stirring 900 rpm. Sample: 15.01 mg/mL polymer, Mn 50000 g/mol (Sigma); solvent purity 99.8 %. Transmission binned per 1 °C (median of Savitzky-Golay filtered cooling-phase points, n=48); observed range 23-100 %. Class thresholds from the source paper: insoluble <10 %, soluble >85 %, partial 10-85 %. Nonequilibrium (0.5 °C/min).	10.1021/acs.jpcb.4c06500	View Cellulose acetate in 1,4-dioxane at 15.01 mg/mL is partially soluble: transmission between 10 and 85 % at some temperature on cooling. Approx. cloud point on cooling ~16 °C. Class refers to nonequilibrium behaviour during the cooling ramp, not thermodynamic solubility. Data: Amrihesari et al., J. Phys. Chem. B 2024 (github.com/mona2442/Polymer-Solubility-Data_Crystal16).
2	Cellulose acetate	1-Octanol	14.98	50000	Partially soluble	48	43	8		Experiment	14.98 mg/mL, 10-60 °C, 0.5 °C/min Crystal16 turbidity (645 nm), cooling ramp 60 to 10 °C at 0.5 °C/min after two heat/cool cycles; holds 120 min at 10 °C and 60 min at 60 and 25 °C; stirring 900 rpm. Sample: 14.98 mg/mL polymer, Mn 50000 g/mol (Sigma); solvent purity 99 %. Transmission binned per 1 °C (median of Savitzky-Golay filtered cooling-phase points, n=186); observed range 8-58 %. Class thresholds from the source paper: insoluble <10 %, soluble >85 %, partial 10-85 %. Nonequilibrium (0.5 °C/min).	10.1021/acs.jpcb.4c06500	View Cellulose acetate in 1-Octanol at 14.98 mg/mL is partially soluble: transmission between 10 and 85 % at some temperature on cooling. Class refers to nonequilibrium behaviour during the cooling ramp, not thermodynamic solubility. Data: Amrihesari et al., J. Phys. Chem. B 2024 (github.com/mona2442/Polymer-Solubility-Data_Crystal16).
3	Cellulose acetate	2,4,6-trimethylpyridine	15.04	50000	Partially soluble	76	80	58		Experiment	15.04 mg/mL, 10-60 °C, 0.5 °C/min Crystal16 turbidity (645 nm), cooling ramp 60 to 10 °C at 0.5 °C/min after two heat/cool cycles; holds 120 min at 10 °C and 60 min at 60 and 25 °C; stirring 900 rpm. Sample: 15.04 mg/mL polymer, Mn 50000 g/mol (Sigma); solvent purity 99 %. Transmission binned per 1 °C (median of Savitzky-Golay filtered cooling-phase points, n=209); observed range 38-95 %. Class thresholds from the source paper: insoluble <10 %, soluble >85 %, partial 10-85 %. Nonequilibrium (0.5 °C/min).	10.1021/acs.jpcb.4c06500	View Cellulose acetate in 2,4,6-trimethylpyridine at 15.04 mg/mL is partially soluble: transmission between 10 and 85 % at some temperature on cooling. Class refers to nonequilibrium behaviour during the cooling ramp, not thermodynamic solubility. Data: Amrihesari et al., J. Phys. Chem. B 2024 (github.com/mona2442/Polymer-Solubility-Data_Crystal16).
4	Cellulose acetate	Acetonitrile	14.96	50000	Soluble	100	100	100		Experiment	14.96 mg/mL, 10-60 °C, 0.5 °C/min Crystal16 turbidity (645 nm), cooling ramp 60 to 10 °C at 0.5 °C/min after two heat/cool cycles; holds 120 min at 10 °C and 60 min at 60 and 25 °C; stirring 900 rpm. Sample: 14.96 mg/mL polymer, Mn 50000 g/mol (Sigma); solvent purity 99.5 %. Transmission binned per 1 °C (median of Savitzky-Golay filtered cooling-phase points, n=51); observed range 100-100 %. Class thresholds from the source paper: insoluble <10 %, soluble >85 %, partial 10-85 %. Nonequilibrium (0.5 °C/min).	10.1021/acs.jpcb.4c06500	View Cellulose acetate in Acetonitrile at 14.96 mg/mL is soluble: clear (T > 85 %) over the whole 10-60 °C cooling ramp. Class refers to nonequilibrium behaviour during the cooling ramp, not thermodynamic solubility. Data: Amrihesari et al., J. Phys. Chem. B 2024 (github.com/mona2442/Polymer-Solubility-Data_Crystal16).
5	Cellulose acetate	Anisole	14.94	50000	Partially soluble	100	100	100		Experiment	14.94 mg/mL, 10-60 °C, 0.5 °C/min Crystal16 turbidity (645 nm), cooling ramp 60 to 10 °C at 0.5 °C/min after two heat/cool cycles; holds 120 min at 10 °C and 60 min at 60 and 25 °C; stirring 900 rpm. Sample: 14.94 mg/mL polymer, Mn 50000 g/mol (Sigma); solvent purity 99 %. Transmission binned per 1 °C (median of Savitzky-Golay filtered cooling-phase points, n=52); observed range 83-100 %. Class thresholds from the source paper: insoluble <10 %, soluble >85 %, partial 10-85 %. Nonequilibrium (0.5 °C/min).	10.1021/acs.jpcb.4c06500	View Cellulose acetate in Anisole at 14.94 mg/mL is partially soluble: transmission between 10 and 85 % at some temperature on cooling. Class refers to nonequilibrium behaviour during the cooling ramp, not thermodynamic solubility. Data: Amrihesari et al., J. Phys. Chem. B 2024 (github.com/mona2442/Polymer-Solubility-Data_Crystal16).

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