Anti-lung cancer activities of polysaccharides from Laminaria japonica: Network pharmacology and structural insights

Authors:

Weihua Jin, Chenghui Lu, Lin Sun, Jing Hou, Zhongshan Zhang, Sanying Wang, Fuming Zhang, Genxiang Mao, Tong Hu

Affiliation:

Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China; School of Life Science, Huzhou University, Huzhou 313000, China; Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310030, China

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Description:

This study investigates the anti-lung cancer activities of polysaccharides extracted from Laminaria japonica, focusing on their bioactive components and molecular mechanisms. Using a network pharmacology approach, key bioactive compounds were identified, and their associated therapeutic targets were predicted. Experimental validation through in vitro assays on human adenocarcinoma (A549) and Lewis Lung Cancer (LLC) cell lines demonstrated that specific polysaccharide fractions, particularly the S-C fraction, exhibited significant inhibitory effects on cancer cell viability, migration, and invasion. In vivo studies further confirmed the S-C fraction's potential in reducing lung metastasis in a mouse model. The results also highlight the structural features of the polysaccharides, particularly their sulfated galactofucan composition, which contributes to their anti-cancer activities. Overall, the study provides an evaluation of L. japonica polysaccharides as promising natural agents for lung cancer therapy, supporting their potential as adjuncts to conventional treatments.

Publications:

Tags:

Biopolymers Carbohydrates Mass spectrometry Modeling and Simulation

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